Bajenaru Daniela (Tazy-vet), Bucharest, Romania
Jack, metis, 5 months, adopted from a shelter and treated against Parvovirus infection.
Prinary lesions: alopecia areas on the head, no other types of lesions were observed.
Two weeks after parvovirosis episode, dermatological problem has begun to progress
Wood’s lamp examination
Microscopic examination of the skin scrapings
Hair plucks (trichoscopy)
Color dilution alopecia and other fololicular dysplasias
Wood’s lamp examination- Negative
Microscopic examination of the skin scrapings- Negative
Trichoscopy- irregular distribution and clumping of melanin which distorts the hair shaft.
Fungal culture- Negative
Fig 1,2,3,4- Trichoscopy examination: large grains of melanin which distorts the hair shaft.
Skin biopsy and histopathology reveal macromelanosomes, melanin clumping and follicular dysplasia.
COLOR DILUTION ALOPECIA
There is no effective treatment for this disorder. The disease is progressive and incurable.
avoiding excessive brushing and shampooing
antimicrobial and keratinolytic products only when needed A high-quality DIET and essential fatty acids
after 6 months
Marina-Ştefania Stroe, DVM
Dog, half breed, M, intact, 4 years old, unvaccinated and without treatment for intestinal parasites, fleas and ticks, 10.2 kg.
The main concern was the ophthalmologic problem.
Three weeks ago he had problems with the hind limbs and he had difficulty in moving. Previous treatments: meloxicam, gentamicin, steroidal anti-inflammatory.
The possibility of ingestion of a toxic (plant / substance) is not excluded.
-white mucous membranes, no lesions in the oral cavity;
-necroses in the auricular pavilions with a visible marginal line, foreskin necrosis, yellow crusts and areas of necrosis predominantly on the posterior limbs, tail, dry-looking fur, which is easily detached;
-after detachment, the skin is denuded, ulcerated, very painful on palpation;
-minimal normal auricular secretion;
-corneal erosions, dry eyes, agglutinated secretions at this level;
-faded cardiac noise; imperceptible pulse;
-rectal examination: doughy feces consistency, normal color;
-abdomen in tension;
-blood pressure (indirect oscilometric metod): 138/102 (112 mmHg).
-Chest and abdomen rx and ultrasonography: free fluid; enlarged spleen.
-Ultrasound guided abdominal puncture: yellowish ascitic fluid, orange tint, after spinning small, white deposit. Protein: 1 g / 100 ml.
-Blood tests: low red blood cell counts, thrombocytopenia, leukocytosis, granulocytosis; elevated liver transaminases, bilirubin and amylase normal values, normal kidney parameters.
-Bleeding time: normal.
-Negative tests for infectious diseases.
-Abdomenocentesis: 335 ml of ascitic fluid and cytological exam: MODIFIED TRANSSUDAT WITH ERYTHROCYTE POLLUTION
Fig. 9: Cutaneous cytology, direct impression smear from necroses of the pinnae (Fig.10): nonsegmentated immature young neutrophils, lymphocytes, few macrophages in whose cytoplasm are found bacilli, bacterial population predominantly represented by bacilli, but also cocci, oxyphilic cell matrix
Fig. 11: Cutaneous cytology, direct impression smear from yellow scale, tail (Fig. 12): neutrophils in all stages: mature segmented, degenerative stage, but also young with eukromatic nucleus and evident nucleoli, macrophages with basophilic cytoplasm, slightly vacuolized, eucromatic nucleus, nucleic streamming, erythrocyte infiltrate.
Fig. 14: Tape prep from yellow scale, hind limb –
keratinocytes on the surface of which are attached cocci, degenerate inflammatory cells
Fig. 13: Trichogram – hair with normal structure, some hair with degraded cuticle, rap A / T: 4/6, follicular cast, negative for demodex and dermatophytes.
Superficial and deep skin scrapes: negative.
-Direct and consensual pupil reflex present;
-Reduced visual acuity;
– Schirmmer test 0 mm / min;
-Florescein test: Positive
Diagnosis: OU Corneal melting ulcer F +
Diagnosis and other differentials
Blood smear, cell morphology: moderate, hypochromic, regenerative anemia,; leukocytosis, neutrophilia, moderate non-specific cellular toxic status, eosinopenia, lymphopenia. In this case, the leukogram (neutrophilia, eosinopenia and lymphopenia) may suggest treatment with corticosteroids, stress, hyperadrenocorticism, severe inflammation (chronic) with various etiologies (viral, bacterial, fungal).
Skin biopsy: histopathological aspects advocate for hyperkeratosis with paracheratosis and chronic inflammatory response involving the epidermis, jonctional area and superficial epidermis.
Histopathological aspects may show Erythema multiforme or TEN (toxic epidermal necrolysis – toxic shock syndrome), which is a late reaction, surprised in a chronic, secondary phase due to fibroblast proliferation.
The toxic shock syndrome may be a reaction to drugs, chemicals or food
Enrofloxacin (dose: 5 mg / kg) at 12h po;
Amoxicillin and clavulanic acid (dose: 20 mg / kg) at 12h po;
Furosemide (dose: 5 mg / kg) at 12h iv;
Tramadol (dose: 2mg / kg) at 12h iv;
Acetylcysteine, Tobrex, Corneregel 6-7 times / day (lack of tears).
Veterinary Clinic Ruse, Bulgaria
Dog , male , entire, five years old was evaluated because of signs of hair loss. The name of the dog is Ares. He lives in apartment with his owners.
About two years ago the dog has easily epilated hairs. The coat is typically thin on the neck , on the head and on the trunk symmetrically. The is crusts on the all body. Some parts of the skin are depigmented. Alopecia is growing to the tail. Hair regrowth non existent.It was unhappy dog.
- Skin tests
- Brushing test- a lot of crusts
- Scotch test – negative
- Cytology – negative
- Scratch test – negative
- Trichogram – more hairs in telogen phase
- Blood test – FT4 7.84 pmol/l
-Levothyroxine 10micrograms/ kg/2twise daily
-Dermoscent – ones a week, for four weeks
– washing with Sebolytic
There are visible results two months after therapy and the dog regained his previous behavior.
Blood test after therapy – FT4 19.17pmol/l
Dr Spas Spasov
United veterinary Clinic Varna, Bulgaria
Fibrosarcoma in rabbits are malignancy rapidly grow soft tissues tumor. Can affect cats dogs and rabbits . The couse of fibrosarcoma in rabbit also can be a viral infection (polyomavirus, malignant rabbit fibroma virus)
Rabbit, female , entire , 5 years old was evaluated because of sings of anorexia and apathy .
The owners reported that a week ago the rabbit progressively stops eating. The last two days it didn’t eat at all. Тhe rabbit has regularly deworming and vaccination.
The rabbit eats hay and rabbit granules only and lives in an apartment and never go outside, there are no others animals in the apartment.
Anorexia, cachexia, apathy, unilateral uveitis, normal temperature (38.5).
Clinical examination revealed all of the body (back, neck, abdomen and all the legs) nodules, which are not painful, mobile, not tempered and pigmented .The size of the nodules was variable from 1 to 5 centimeters.
Some nodules were ulcerated and bleeding, and still painless. Such formations are not observed in the nose and the ears, and the front part of the head.
We did not find any abnormalities on the X-ray examination of the chest and abdomen. A nodule was surgically removed by cutting.
Symptomatic therapy was appointed until the results of the histopathological examination:
Metoclopramide-0,5mg / kg
Ranitidine-4 mg / kg
Simethicone-65mg / rabbit
Meloxicam-1mg / kg
Enrofloxacin, 10 mg / kg
Intravenous infusion Hartman 4ml / kg / hour.
So designated therapy lasted about 10 days pending the results of pathological examination The condition of the animal slightly improved, which is expressed in phrases in appearance of appetite. The animal took small amounts of food.
The prognosis for this type of tumors is garded to poor. Because of poor condition of the patient and the prognosis owners decided to euthanased the rabbit.
First Congress of Bulgarian Association of Veterinary Dermatology held in 27-28th of April, 2017 at city of Plovdiv, Bulgaria. There were more then 120 veterinarians from Bulgaria, Macedonia, Romania, Greece and Cyprus.
Dr. Emmanuel Bensignor and Dr. Sebastian Viaud, who impressed the audience with the way information was provided, but also the way all the scientific information was presented so to be useful in every-day-practice. They discussed which one is the best elimination diet, which medicine is effective in the control of canine atopic dermatitis and how to use them appropriately? How to do Desensibilisation therapy? How to perform biopsy from unusual places? How to recognize vasculite lesion and how to deal with it?
Vets on The Balkans support BAVD submit one free ticket for 4th Latin American Congress of Veterinary Dermatology to be held in
Merida, Mexico from 13th to 16th of June 2018 and one free ticket for 4th Romanian Dermatology Congress , October, 2017. Their members are presenting clinical reports and the best one will win. All of the cases will be posted in the journal Vets on The Balkans.
Dr Ana Maria Boncea, Vetderm Therapy in Bucharest, Romania
“I would like to thank you one more time for this opportunity. It was great event!! Congratulations for everything! See you soon!!”
Dr Daniela Bajenaru, Tazy Vet Veterinary Clinic in Bucharest, Romania
“Dear Luba, the 1st Bulgarian Veterinary Dermatology Congress was excellent, the lecturers gave us a lot of useful information and the organization was great!”
Dr Adriana Cosma, Conforvet on Bucharest, Romania.
“ Hi Luba! I wanted to tell you that we thank you for everything…we had wonderful time. We liked very much the BAVD Congress and the city of Plovdiv!”
The team of Vets on The Balkans congratulated BAVD for the high professional level of organizing and the brilliant scientific program.
Tazyvet veterinary clinic
Singalment and hystory
Bella, presented on 12/13/2016
10 year old, female, Labrador retriever
5 month history of polydipsia, polyuria, polyphagia and pruritus
Thin, hypotonic skin, easy bruising
Calcinosis cutis over the dorsal neck, thorax and rump
Serum chemistry panel
Trichogram, scoch test
ACTH stimulation test
Urinalysis – low specific gravity (1.005)
Coagulation time – 5’
Serum chemistry panel: GPT -361, ALP>1980, CHOL- 215, CREA -0,587, UREA -25,2
Trichogram/ scoch test – no significant findings
Bacteriological ex. – Staphylococcus aureus (++++)
Basal cortisol level > 10 µg
ACTH stimulation test – cortisol= 29,4 µg/dl
CANIN HYPERCORTISOLISM (CUSHING SYNDROM)
SUSPICION: PITUITARY DEPENDENT
TRILOSTANE -120 mg once daily
Amoxicillin with clavulanic acid -12,5 mg/kg/12h, 30 days
Topical: – moisturizing and desinfectant shampoo, once weekly
– antiseptic, anti inflammatory and healing gel, once daily
Diet: low fat
After 3 days of topical treatment
Basal cortisol level > 10 µg/dl
The evolution to be continued ….
Dr Iva Nikolova
Veterinary Clinic Dobro Hrumvane
Cutaneous asthenia has also been called Ehlers-Danlos syndrome (EDS), Dermal fragility syndrome, Dominant collagen dysplasia and Dermatosparaxis. EDS is a group of inherited connective tissue diseases ,characterized by defects in collagen production. This results in a variety of clinical signs including loose, hyperextensible, fragile skin, joint laxity and other connective tissue dysfunctions. Clinical signs include fragile skin from the time of birth, wounds that heal with thin scars, delayed wound healing, pendulous skin, hematoma and hygroma formation.
Lucko, 7-month-old shorthair male mix breed cat, was represented to the clinic with uveitis, alopecia and multiple skin ulcerative wounds, located in the regions of the dorsum, thorax and head. He was treated for few months with antibiotics, ointments and corticosteroids with no success. The skin of the cat was extremely extensible and very fragile. It was very easy for the skin to be torn but with no bleeding at all. The cat had to be handle with gentle touch and care.
The diagnostic work-up included a complete blood count, blood serum biochemistry panel and urinalysis to rule out any internal disease associated with these skin lesions. CBC showed mild leucocytosis (white blood cell count: 19.5 x 10^9, reference range: 5.0 x 10^9 –18.9 x 10^9). In biochemistry analisys the changes were CK – 225 U/L (reference range: 17.00 – 150.20 U/L) and LDH – 427 U/L (reference range: 35.10 – 224.90 U/L).
The rapid test of Feline Immunodeficiency Virus and Feline Leukemia Virus (IDEX FIV/FeLV) were found to be negative. Feline Herpes Virus PCR – negative. Dermafyt KRUUSE test – negative. Microbiology of skin lesions – negative. The low-dose dexamethasone suppression test – negative for Cushing disease.
Punch biopsy of the skin was performed together with dr Rares Capitan and sent for histological investigation in Romania. The histopathologic findings were compatible with Feline Cutaneous Asthenia.
Feline Cutaneous Asthenia is a rare, inherited disorder of collagen production in cats. There is no cure, but consistent management can allow affected cats to have long life. Owners should be trained to handle the affected cat with gentleness and to avoid traumas.
A. MARTIN CORDERO
*VETDERM: Dermatologia Veterinaria Especializada, Guadalajara, Mexico
Assistant professor Department of Veterinary Medicine, Centro Universitario de Ciencias Biologicas y Agropecuarias, University of Guadalajara; Guadalajara, Jalisco, Mexico
A male non neutered 9 year-old Akita was presented with alopecic focal crusty lesions on rear and front limbs. Hemorrhagic lesions were observed on the front limb and history of tick infestation was provided by the owner. Ulcerative and nodular lesions were present on the right lateral aspect of the face. Skin scraping revealed presence of Demodex injai. . ELISA rapid testing IDEXX 4DX was performed to confirm tick borne disease revealing positivity to Anaplasma spp. Skin biopsies were taken from the face and abdomen revealing large atypical lymphocytes with epitheliotrophism consistent with epitheliotrophic lymphoma. The patient was presented one month later with pleural effusion, euthanasia was performed.
A male non-neutered 9 year old Akita was presented with history of focal crusty lesions. Due to his geographic origin from the North of Mexico close to the border with the United States and comments from the owner about tick infestation an ELISA SNAP 4dx plus test (Idexx) was performed.
SNAP test was positive to Anaplasma spp.
CBC showed no abnormalities.
Cutaneous lesions observed include, crusty and erythematous lesions in the abdominal regions, crusts, erosion and ulceration in the muzzle and petechial and ecchymosis in the front left limb.
A deep skin scraping was performed revealing the presence of long body Demodex compatible with Demodex injai.
Treatment with weekly Doramectin at 0.5mg/kg was started in conjunction with Doxycycline at 10mg/kg per day.
After 5 weeks of treatment owner reported depression and decrease of food ingestion, also, the appearance of new lesions in the muzzle region. Physical examination show nodular and plaque erythematous formations in the face and ventral region.
Three biopsies were taken using a 6mm punch biopsy and sent to dermatopathological examination. Results of the biopsy showed large atypical lymphocytes with epitheliotrophism consistent with epitheliotrophic lymphoma.
Demodectic mange may appear in a juvenile or adult onset presentation, as well as generalized or localized form. Patients with adult presentation should be screened in search for underlying conditions. In most cases underlying conditions will not be found. In order to control the disease, primary cause should be treated and corrected1.
Correct approach to dermatological conditions include a well-detailed clinical history and diagnostic test according to lesions found. We should be aware of perform all the diagnostic dermatological test we need, du to the fact, there are several dermatosis associated with secondary factors or associated conditions.
1.- Mueller, R. S., Bensignor, E., Ferrer, L., Holm, B., Lemarie, S., Paradis, M., & Shipstone, M. A. (2012). Treatment of demodicosis in dogs: 2011 clinical practice guidelines. Veterinary Dermatology, 23(2), 86–e21
” What are the causes of hair loss? Focal and diffuse alopecia”
was the subject at 2nd Annual Dermatology Congress of SRDV in Bucharest, Romania. Speakers were : Professor David Lloyd – PhD, DipECVD; Anette Loeffler – DrMedVet PhD DVD DipECVD MRCVS; John Hardy – DVM Dipl ECVD, Prof. Viorel Andronie, Dr. Rares Capitan – Resident ECVD, Dr. Boncea Ana-Maria – Resident ECVD, Daniela Enache – DVM. M.Sc. PhDS
The Romanian Veterinary Dermatology Society (SRDV) is an association founded in 2014 by eight veterinarians and university professors from different institutions, all of them driven by the same passion for Veterinary Dermatology.
All of the income and profits obtained from sponsorships, taxes, congresses and professional meetings, are dedicated to our current activities such as specific event organization, scientific and research activities and other initiatives of common interest for its members. The official language is Romanian.
SRDV is task oriented in publishing original studies realized with classic and modern methods in the field of Veterinary Dermatology and Dermatopathology and related departments, registering as a society who promotes professional and medical knowledge.
Also, The Romanian Veterinary Dermatology Society (SRDV) is oriented towards forming and promoting opinions about the research made in the field of Veterinary Dermatology and it is engaged as well in maintaining a dialogue or sharing thoughts about the research and its impact on the Dermatology practice.
Our goals include improving our clinical experience, organizing high quality scientific events attended by international figures from ECVD and ACVD, and publishing clinical cases or specific cases that need a special clinical approach. SRDV particularly addresses to veterinarians, but other professions related to this field are targeted as well.
At the same time, SRDV will translate in Romanian and offer to its members for medical guidance, different Guides of Procedures and Diagnostic and Therapeutic Protocols, known and recognized worldwide.
The team of Vets on The Balkans were guests at the congress and we would like to express our gratitude to SRDVand especially to Dr Rares Capitan!
Our colleague Dr Daniela Enche was a speaker there, proud of you!
More info : http://www.srdv.ro/