Cutaneous neutrophilic panniculitis and vasculitis in a shar-pei associated with autoinflammatory disease

Okan-KahramanDr. Okan Kahraman, DVM

İkon veterinary clinic

İstanbul/ turkey



A 5-year-old neutered male Shar-Pei presented to the dermatology service with swelling and ulcerative crusted lesions on the flanks and chest.

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The patient was clinically diagnosed with Shar-Pei Autoinflammatory Disease (SPAID), characterized by recurrent episodes of fever and lethargy occurring once or twice annually, resolving spontaneously or with the use of non-steroidal anti-inflammatory drugs (NSAIDs).


Cytological examination

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Cytological examination of the skin lesion revealed a neutrophilic infiltrate with infectious agents (coc bacteri) , compatible with neutrophilic dermatitis-panniculitis.

Treatment and outcome:

Treatment was 1mg/kg prednisolon oral tablets (24h) 10 days than reduce dosis

Rilexine (virbac) 300 mg twice Daily 15 days

Antibacterial shampoo weekly

The neutrophilic panniculitis and vasculitis observed in this case responded well to anti-inflammatory corticosteroid therapy, implying

an underlying autoinflammatory condition as the etiology of the skin lesions.


1 weeks later

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2 moths later

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The power of local therapy in superficial bacterial infections- part 1

67668506_2745972975432468_1475995593221341184_nDr Spas Spasov

Veterinary center Dr Antonov

Varna, Bulgaria



A topic not only for dermatologists.

“Recent high-profile reports warn of the dangers of not taking action. A bleak report by economist Jim O’Neill, commissioned by the British government and released in May, estimates that 700 000 deaths globally could be attributed to AMR this year and that the annual toll would climb to 10 million deaths in the next 35 years. The report projects US$ 100 trillion in losses by 2050 if nothing is done to reverse the trend.”

Aa quote from the World Health Association website.

1.Clinical case of Azar .86809005_225664251788761_2987290882698379264_n



Azar is a 3 years old cane corso dog.

There is a regular   vaccination  and tick and flea teratments  with tablets (isoxazolines).

Case history .

A month and a half ago, the owner has taken Azar to another clinic because of the many  pustules on the dog’s chin.

Clinical symptoms include itching in the facial area, redness, and many of about 0.5 cm pustules all over the chin.86720876_1100028783670155_9119763329592590336_n
Systemic antibiotic therapy and topical once-daily chloroxidine therapy were prescribed for Azar.

Two weeks later there was no change in the condition  of the dog.

Bacteriology and antibiogram were performed( Staph. Aureus ) , a second systemic antibiotic was added after the result (the first antibiotic was discontinued).

Staphyococcus aureus is extracted from the antibiogram.

Both antibiotics show the sensitivity of the causative agent.

Two weeks after the second antibiotic, there was no change in Azar’s condition.

  1. Clinical presentation

At the initial examination, Azar was in good general condition, but there were numerous pimples throughout the chin area, which were very easily bleeding and pussing.

In addition, Azar defecates 3-5 times a day and most times the stools are not well formed.

  1. We did cytology and deep scraping of the skin.

Mass neutrophils, macrophages, and cocci bacteria.


Skin scraping
No demodex or other parasites of deep skin scraping.


Initial therapy:

Local therapy with daily chloroxiderm shampoo, duxo pio tampons and duxo seb spot form and Diprogenta 0.5 mg / 1 mg / g cream

betamethasone / gentamicin for 10 days.

The effect after the first 10 days is significant and more than satisfactory, so the therapy prescribed after day 10 was changed only with shampoo with peptide.

10 days later, there were almost no signs of infection.

10 days later, Azar’s therapy was limited to once daily administration of the duxo self-tampons and once a week the duxo-seb spot form, as well as a curative diet with the Analergenic diet.


There are no signs of bacterial infection now, gastrointestinal symptoms are no longer observed, and therapy is just cleansing with duxo swabs (suitable for daily use).




Chin furunculosis and suspected food allergy.